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Radical new solution to the gaps and inconsistencies in the current understanding of the mechanism of haem-centred NOS catalysis
|This paper offers a radical, new solution to the gaps and inconsistencies in the current understanding of the mechanism of haem-centred NOS catalysis, which also challenges the other existing paradigm of cobalamin as just an .NO mop. Examination of a wide diversity of NOS and cobalamin-dependent enzyme structure-function studies, as well as data from the .NO/cobalamin chemical, biochemical, immunological, genetic, and clinical literature, offers indications that cobalamin, specifically, in one of its active forms, adenosylcobalamin (AdoCbl), may have a third, eukaryotic coenzyme function as the principal cofactor of well-regulated NOS catalysis in vivo.|
Vol 3, No 1 (2013)
Table of Contents
|Application of a Hypothesis to Speciation in Hominidae|
|George Edward Parris||2-5|
|Nutrient Loading Increases Red Snapper Production in the Gulf of Mexico|
|Joshua M. Courtney, Amy C. Courtney, Michael W. Courtney||7-14|
|Possible roles of sphingolipids in clathrin-mediated endocytosis - Vesicle formation by a glycerophospholipid cycle - a hypothesis|
|Sybille G. E. Meyer||15-22|