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Hypotheses in the Life Sciences is undergoing a change of publisher and is not currently accepting submissions through the web site any more. Further information will be posted once arrangements have been finalised. |
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| Posted: 2014-03-28 | |
Radical new solution to the gaps and inconsistencies in the current understanding of the mechanism of haem-centred NOS catalysis |
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| This paper offers a radical, new solution to the gaps and inconsistencies in the current understanding of the mechanism of haem-centred NOS catalysis, which also challenges the other existing paradigm of cobalamin as just an .NO mop. Examination of a wide diversity of NOS and cobalamin-dependent enzyme structure-function studies, as well as data from the .NO/cobalamin chemical, biochemical, immunological, genetic, and clinical literature, offers indications that cobalamin, specifically, in one of its active forms, adenosylcobalamin (AdoCbl), may have a third, eukaryotic coenzyme function as the principal cofactor of well-regulated NOS catalysis in vivo. | |
| Posted: 2012-10-29 | |
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ISSN: 2042-8960